Influenza A virus Essay Example | Topics and Well Written Essays - 500 words

Influenza A virus - Essay Example The envelope has two surface glycoproteins called neuraminidase and hemagglutinin, the latter gets attached to the host cell prior to viral penetration. Often the HA protein undergoes several antigenic changes, such genomic alterations lead to phenotypic changes thus challenging the development of vaccines against influenza virus. [A. Maher and A virulent influenza A virus in humans is responsible for the infection of the respiratory tract leading to necrosis of the epithelial tissues. The infection then extends to the bronchioles and alveoli resulting in interstitial pneumonia. A susceptibility to bacterial super infection is not uncommon. The infection slowly affects extra respiratory tissues leading to myocarditis, myositis, parotitis, encephalopathy and Reye-Jhonson syndrome. [T. Kuiken, G. F. Rimmelzwaan, G. Van Amerongen and A. D. M. E. Osterhaus] For most experimental studies concerned with animal models, mouse is widely used .The low cost combined with its small size permits researchers to conduct large scale studies. Mouse is also considered suitable as a mammalian model for the studies concerning pathogenesis and immunity of human H5N1 influenza virus mainly due to the fact that this virus replicates very effectively and efficiently in the lungs of mouse without any adaptation.